Early life antibiotic exposure and inflammatory bowel disease

Inflammatory bowel disease (IBD) is known to affect millions of people worldwide and primarily caused due abnormal immune responses intestinal microbes. IBD categorized under two main types – ulcerative colitis Crohn’s disease. Although the cause still an unsolved puzzle, its development can be attributed presence various risk factors including antibiotic use. The system point genesis anything that creates imbalance trigger IBD. Alterations in gut microbiota lead reduced microbial populations a chronic inflammation state. Antibiotics may influence maturity hamper formation strong system. This makes individual vulnerable threat infections subsequent Studies have implicated use antibiotics during pregnancy, antepartum, among neonates associated with Adequate niche takes place within first 2 years life extensive administration this period pose significant for Animal studies also documented role utero exposure antepartum developing offspring. review summarizes pregnancy infancy